Dr. Ivo Ruttekolk

  • "Patente auf Nahrungsmittelkomponenten – auch jenseits von Genfood" [Patents on food components—even beyond gene food]; BIO Deutschland Jahrbuch 2016/2017, p. 44
  • "Kosteneffizient zum Patentschutz - Eine Kostenanalyse aus der Praxis [Costefficient patent protection—a practical cost analysis]"; IP-Seminar July 2016, TP ConferenceCentre, Heidelberg
  • "Der Schatten des zahnlosen § 34a PatG – Mögliche Konsequenzen des Inkrafttretens des Nagoya-Protokolls für die Praxis" [The Shadow of the ineffectual § 34a PatG – Possible impact of the implementation of the Nagoya Protocol in practice]; Mitteilungen der deutschen Patentanwälte, No. 10/2015, pp. 434-439
  • "Nagoya-Protokoll: Neues zur Nutzung genetischer Ressourcen" [Nagoya Protocol: News Regarding the Use of Genetic Ressources]; BIOspektrum, No. 1/2015, p. 111, Springer-Verlag – Heidelberg
  • "Zur Vertraulichkeit von Internetrecherchen" [Regarding the Confidentiality of Internet Research]; Thorsten Brüntjen, Ivo Ruttekolk, Andrea Teschemacher, GRUR 2013, No. 9, p. 897-902
  • "Änderung des § 34a PatG – Nennung genetischer Ressourcen in deutschen Patentanmeldungen" [Revision of § 34a PatG – Requirements for the Use of Genetic Resources in German Patent Applications]; BIO Deutschland Rechtsinfo aktuell August 2016

Scientific publications

  • A peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction. Witsenburg JJ, Sinzinger MD, Stoevesandt O, Ruttekolk IR, Roth G, Adjobo-Hermans MJ, Brock R. 2015, Chembiochem. 16(4):602-10.
  • Peptide microarrays to probe for competition for binding sites in a protein interaction network. Sinzinger MD, Ruttekolk IR, Gloerich J, Wessels H, Chung YD, Adjobo-Hermans MJ, Brock R. 2013, J Proteomics. Aug 26;89:71-80.
  • Multivalent design of apoptosis-inducing bid-BH3 peptide-oligosaccharides boosts the intracellular activity at identical overall peptide concentrations. Richter M, Chakrabarti A, Ruttekolk IR, Wiesner B, Beyermann M, Brock R, Rademann J. 2012, Chemistry. 18(52):16708-15.
  • The intracellular pharmacokinetics of terminally capped peptides. Ruttekolk IR, Witsenburg JJ, Glauner H, Bovee-Geurts PH, Ferro ES, Verdurmen WP, Brock R. 2012, Mol Pharm. 9(5):1077-86.
  • Coupling to polymeric scaffolds stabilizes biofunctional peptides for intracellular applications. Ruttekolk IR, Chakrabarti A, Richter M, Duchardt F, Glauner H, Verdurmen WP, Rademann J, Brock R. 2011, Mol Pharmacol. 79(4):692-700.
  • Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: implications for uptake. Verdurmen WP, Thanos M, Ruttekolk IR, Gulbins E, Brock R. 2010, J Control Release. 147(2):171-9.
  • Simultaneous detection of intracellular target and off-target binding of small molecule cancer drugs at nanomolar concentrations. Glauner H, Ruttekolk IR, Hansen K, Steemers B, Chung YD, Becker F, Hannus S, Brock R. 2010, Br J Pharmacol. 160(4):958-70.
  • A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency. Duchardt F, Ruttekolk IR, Verdurmen WP, Lortat-Jacob H, Bürck J, Hufnagel H, Fischer R, van den Heuvel M, Löwik DW, Vuister GW, Ulrich A, de Waard M, Brock R. 2009, J Biol Chem. 284(52):36099-108.
  • The in vitro biological activity of the HLA-DR-binding clinical IgG4 antibody 1D09C3 is a consequence of the disruption of cell aggregates and can be abrogated by Fab arm exchange. Hansen K, Ruttekolk IR, Glauner H, Becker F, Brock R, Hannus S. 2009, Mol Immunol. 46(16):3269-77.
  • HPMA as a scaffold for the modular assembly of functional peptide polymers by native chemical ligation. Ruttekolk IR, Duchardt F, Fischer R, Wiesmüller KH, Rademann J, Brock R. 2008, Bioconjug Chem. 19(10):2081-7.

Books and book chapters:

  • Book chapter in “Measurements of the intracellular stability of CPPs” in “Cell-Penetrating Peptides – Methods and Protocols”, 2011, Humana Press, Springer, ed. Ülo Langel.
  • Dissertation “Investigation of the Cellular Pharmacology of Peptidic and Non-Peptidic Compounds”, 2010, Faculty of Chemistry and Pharmacy at the University of Tübingen, Germany.